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General, Organic, and Biological Chemistry

This course provides an integrated introduction to general, organic, and biological chemistry, designed primarily for students pursuing careers in health-related fields such as nursing, allied health, or nutrition. The courseware can be modified to fit a one or two semester sequence.

Description

This course provides an integrated introduction to general, organic, and biological chemistry, tailored for students pursuing careers in health-related fields such as nursing, allied health, or nutrition. It covers fundamental topics including atomic structure, chemical bonding, reactions, states of matter, solutions, acids and bases, and the principles of organic and biochemical processes. Emphasis is placed on the relevance of chemistry to biological systems and human health, with practical applications in physiology, pharmacology, and metabolism.

The courseware is designed to offer contextualized, engaging content presented in a logical sequence. It features smooth transitions between concise expository text, worked examples, interactive activities, simulations, and multimedia elements. This dynamic structure supports active learning and helps students build a deeper understanding of chemical principles through real-world context and application.

What students will learn

By the time they finish this course, students will learn or be able to:

  • Describe and apply basic principles of general chemistry in organic and biological contexts, including atomic and molecular structure, chemical reactions, nuclear chemistry, solutions,  intermolecular forces and acids and bases.
  • Interpret and use chemical notation, including formulas, equations, and nomenclature for inorganic, organic, and biochemical compounds.
  • Explain the structure, properties, and reactions of organic molecules, with a focus on functional groups relevant to biological systems (e.g., alcohols, acids, esters, amines).
  • Identify and describe the roles of biomolecules such as carbohydrates, lipids, proteins, and nucleic acids in human physiology and metabolism.

Learning objectives by module

Part 1: General Chemistry

Unit 1, Matter, Measurement and Energy

Module 1, Basic Concepts of Matter

  • Describe the three states of matter.
  • Classify matter as element, compound or mixture.
  • Describe physical and chemical changes and properties.

Module 2, Measurements

  • Use the International System of Units for measurements.
  • Record measurements and calculations using the correct number of significant figures.
  • Determine the accuracy and precision of sets of data.
  • Convert units using dimensional analysis.
  • Determine the density of a substance. 
  • Calculate medication dosages based on patient-specific factors, such as weight and prescribed dosage guidelines.

Module 3, Energy, Heat and Temperature

  • Distinguish between kinetic and potential energy.
  • Recognize the relationship between heat, temperature and kinetic energy.
  • Distinguish between exothermic and endothermic reactions.
  • Convert among the temperature scales of Fahrenheit,Celsius, and Kelvin.
  • Convert among units of energy.
  • Apply the specific heat equation to solve for unknown variables.

 

Unit 2, Atomic Structure and Nuclear Chemistry

Module 4, Atomic Structure and the Periodic Table

  • Describe the structure of the atom and its subatomic particles.
  • Describe the arrangement of the periodic table of elements.
  • Interpret chemical symbols for isotopes and ions.
  • Apply the concepts of isotopes and their percent abundance to perform calculations related to atomic mass.

Module 5, Arrangement of Electrons

  • Describe the arrangement of electrons in an atom with electron configurations and orbital diagrams for elements.
  • Determine numbers of valence electrons for main-group elements.
  • Compare relative sizes and ionization energies of atoms of different elements.

Module 6, Nuclear Chemistry

  • Explain and use mathematical relationships among frequency, wavelength, and energy to analyze electromagnetic radiation.
  • Write nuclear equations for alpha, beta and gamma radioactive decay.
  • Apply the concept of half-life to calculate the time for radioactive decay and the remaining mass of an isotope over time.
  • Analyze the effects of radiation exposure and apply principles of nuclear chemistry to explain the medical and biological applications of radioisotopes.

 

 Unit 3, Ionic and Molecular Bonding and Compounds

Module 7, Ionic and Molecular Bonding and Compounds

  • Describe ionic and covalent bond formation.
  • Write electron configurations for ions.
  • Name and write chemical formulas for compounds.

Module 8, Structure of Molecular Compounds

  • Recognize differences between molecular and structural formulas.
  • Draw Lewis structures depicting the bonding in molecules.
  • Assess the polarity of covalent bonds.

Module 9, Molecular Structure and Polarity

  • Predict the structure of molecules using valence shell electron pair repulsion (VSEPR) theory.
  • Assess the polarity of a molecule based on its bonding and structure.

 

Unit 4, Chemical Reactions

Module 10, Chemical Reactions and Equations

  • Represent chemical reactions with chemical equations.
  • Classify chemical reactions.
  • Predict the products of chemical reactions.
  • Describe oxidation-reduction reactions.

Module 11, Mole Conversions

  • Convert amounts of substances among moles, particles and mass.

Module 12, Quantities in Chemical Reactions

  • Apply stoichiometric relationships to calculate amounts of substances involved in chemical reactions.
  • Identify limiting reactants in chemical reactions.
  • Calculate the percent yield of a chemical reaction.
  • Distinguish between exothermic and endothermic reactions.

Unit 5, Solids, Liquids and Gases

Module 13, States of Matter and Intermolecular Forces

  • Compare and contrast intermolecular and intramolecular forces.
  • Explain how temperature affects the strength of intermolecular forces and determines the state of matter of a substance.
  • Predict and explain differences in melting points and boiling points of ionic and molecular compounds.

Module 14, Gases

  • Describe the relationship between the kinetic molecular theory and gas laws.
  • Calculate pressure, temperature, volume, or amount of gas by applying the appropriate gas law.

Unit 6, Solutions

  • Learning Objectives Available Soon

Module 15, Overview of Solutions

Module 16, Concentrations of Solutions

Unit 7, Reaction Rates and Equilibrium

  • Learning Objectives Available Soon

Module 17, Basic Concepts of Equilibrium and Reaction Rates

Module 18, Le Chatelier’s Principle and Equilibrium Calculations

Unit 8, Acids and Bases

  • Learning Objectives Available Soon

Module 19, Defining and Measuring Acids and Bases

  • Learning Objectives Available Soon

Module 20, Strong and Weak Acids and Bases

  • Learning Objectives Available Soon

Module 21, Buffers

  • Learning Objectives Available Soon


Part 2, Organic Chemistry

Unit 1, Overview of Organic Chemistry

Module 1, Overview of Organic Chemistry

  • Determine whether a substance is an organic compound based on its chemical formula.
  • Write Lewis structures for organic compounds.
  • Explain the importance of functional groups and recognize their common representations.
  • Classify oxygen-containing functional groups.
  • Classify nitrogen-containing functional groups.


Unit 2, Hydrocarbons

Module 2, Alkanes

  • Translate between structural, condensed and line formulas for alkanes.
  • Apply the IUPAC rules to name straight-chain, branched and cyclo alkanes.
  • Analyze structures to determine if they are isomers or non-isomers.

Module 3, Alkenes, Alkynes and Aromatics

  • Apply the IUPAC rules to name alkenes, alkynes and aromatics.
  • Describe the molecular structure of alkenes, alkynes and aromatics.

Module 4, Properties and Reactions of Hydrocarbons

  • Learning Objectives Available Soon

Unit 3, Oxygen and Nitrogen Containing Organic Compounds

  • Learning Objectives Available Soon

Module 5, Alcohols and Ethers

  • Learning Objectives Available Soon

Module 6, Aldehydes and Ketones

  • Learning Objectives Available Soon

Module 7, Carboxylic Acids and Esters

  • Learning Objectives Available Soon

Module 8, Amines and Amides

  • Learning Objectives Available Soon


Unit 4, Biological Macromolecules

  • Learning Objectives Available Soon

Module 9, Carbohydrates

  • Learning Objectives Available Soon

Module 10, Lipids

  • Learning Objectives Available Soon

Module 11, Amino Acids and Proteins

  • Learning Objectives Available Soon

Module 12, Enzymes

  • Learning Objectives Available Soon

Module 13, Nucleic Acids

  • Learning Objectives Available Soon

 

Unit 5, Metabolism

Module 14, Metabolism and Energy

  • Learning Objectives Available Soon

Module 15, Metabolism of Carbohydrates

  • Learning Objectives Available Soon

Module 16, Metabolism of Lipids and Amino Acids

  • Learning Objectives Available Soon

Course assessments, activities, and outline

Each module concludes with a comprehensive module checkpoint.

 

Part 1: General Chemistry

Unit 1, Matter, Measurement and Energy

Module 1, Basic Concepts of Matter

Module 2, Measurements

Module 3, Energy, Heat and Temperature

 

Unit 2, Atomic Structure and Nuclear Chemistry

Module 4, Atomic Structure and the Periodic Table

Module 5, Arrangement of Electrons

Module 6, Nuclear Chemistry

 

 Unit 3, Ionic and Molecular Bonding and Compounds

Module 7, Ionic and Molecular Bonding and Compounds

Module 8, Structure of Molecular Compounds

Module 9, Molecular Structure and Polarity

 

Unit 4, Chemical Reactions

Module 10, Chemical Reactions and Equations

Module 11, Mole Conversions

Unit 5, Solids, Liquids and Gases

Module 13, States of Matter and Intermolecular Forces

Module 14, Gases

Unit 6, Solutions

Module 15, Overview of Solutions

Module 16, Concentrations of Solutions

Unit 7, Reaction Rates and Equilibrium

Module 17, Basic Concepts of Equilibrium and Reaction Rates

Module 18, Le Chatelier’s Principle and Equilibrium Calculations

Unit 8, Acids and Bases

Module 19, Defining and Measuring Acids and Bases

Module 20, Strong and Weak Acids and Bases

Module 21, Buffers

 

Part 2, Organic Chemistry

Unit 1, Overview of Organic Chemistry

Module 1, Overview of Organic Chemistry

Unit 2, Hydrocarbons

Module 2, Alkanes

Module 3, Alkenes, Alkynes and Aromatics

Module 4, Properties and Reactions of Hydrocarbons

 

Unit 3, Oxygen and Nitrogen Containing Organic Compounds

Module 5, Alcohols and Ethers

Module 6, Aldehydes and Ketones

Module 7, Carboxylic Acids and Esters

Module 8, Amines and Amides

 

Part 3, Biological Chemistry

 

Unit 4, Biological Macromolecules

Module 9, Carbohydrates

Module 10, Lipids

Module 11, Amino Acids and Proteins

Module 12, Enzymes

Module 13, Nucleic Acids

 

Unit 5, Metabolism

Module 14, Metabolism and Energy

Module 15, Metabolism of Carbohydrates

Module 16, Metabolism of Lipids and Amino Acids

Other course details

The current courseware comprehensively covers all topics at a depth suitable for a two-semester course, but it is also designed to be adaptable for a one-semester format when necessary.

August 2025

NOTE: General Chemistry (Part 1) will be available in Fall 2025. The complete course—General (Part 1) and Organic and Biological Chemistry (Part 2)—will be released in Spring 2026.

The General Chemistry portion is adapted from OLI General Chemistry (which was originally adapted from OpenStax General Chemistry), while the Organic and Biological sections are based on The Basics of General, Organic, and Biological Chemistry. Ball, Hill and Scott, 2011.

Core Development Team

  • Dhaval Doshi (Mt. San Antonio College)
  • Sandra Raysor (Carnegie Mellon University)
  • Colleen Kelley (University of Arizona)
  • Gino Romeo (Yavapai College)
  • Pollyanna Wikrent (Pima College)
  • Cuiwen He (Mt. San Antonio College)
  • Steven Bernard (Mt. San Antonio College)
  • Michael Marsella (Mt. San Antonio College)

System requirements

OLI system requirements, regardless of course:

  • internet access
  • an operating system that supports the latest browser update
  • the latest browser update (Chrome recommended; Firefox, Safari supported; Edge and Internet Explorer are supported but not recommended)
  • pop-ups enabled
  • cookies enabled

Some courses include exercises with exceptions to these requirements, such as technology that cannot be used on mobile devices.

This course’s system requirements:

  • A full desktop operating system, such as Windows or Mac OS X.
  • Flash
  • Java

Cost and payment options

$25 per student

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